tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate
tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate
CAS: 211108-50-8
Molecular Formula: C10H16FNO3
tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate - Names and Identifiers
tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H16FNO3 |
| Molar Mass | 217.24 |
| Density | 1.15±0.1 g/cm3(Predicted) |
| Melting Point | 88-90℃ |
| Boling Point | 288.7±40.0 °C(Predicted) |
| Flash Point | 128.413°C |
| Vapor Presure | 0.002mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | -3.61±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.466 |
tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36 - Irritating to the eyes R52 - Harmful to aquatic organisms |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate - Introduction
tert-butyl is an organic compound with the chemical formula C10H16FNO3. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless liquid or solid
-Molecular weight: 213.24g/mol
-Melting point: 38-40 ° C
-Boiling point: 220-222 ° C
-Flash point: 92 ° C
-Solubility: Soluble in organic solvents, such as ethanol, acetone
Use:
- tert-butyl is an organic synthesis intermediate commonly used in the preparation of other organic compounds.
-It also has certain application value in the field of medicine and can be used to synthesize drugs.
Method:
The preparation method of tert-butyl is as follows:
1. Reaction of tert-butyl 3-amino-1-carboxylate with hydrogen fluoride under appropriate reaction conditions to give tert-butyl 3-fluoro-1-carboxylate.
2. Reaction of tert-butyl 3-fluoro-1-carboxylate with 4-chloropiperidine under basic conditions gives tert-butyl 3-fluoro-4-chloropiperidine-1-carboxylate.
3. Finally, 3-fluoro-4-chloropiperidine-1-carboxylic acid tert-butyl ester is oxidized to obtain the final product tert-butyl.
Safety Information:
- tert-butyl is an organic compound with certain toxicity and should comply with laboratory safety procedures.
-Avoid contact with skin and eyes, pay attention to protective measures.
-During storage and handling, attention should be paid to prevent ignition and electrostatic sparks.
-If taken by mistake or inhaled, seek medical attention immediately and provide the appropriate safety data sheet.
Nature:
-Appearance: Colorless liquid or solid
-Molecular weight: 213.24g/mol
-Melting point: 38-40 ° C
-Boiling point: 220-222 ° C
-Flash point: 92 ° C
-Solubility: Soluble in organic solvents, such as ethanol, acetone
Use:
- tert-butyl is an organic synthesis intermediate commonly used in the preparation of other organic compounds.
-It also has certain application value in the field of medicine and can be used to synthesize drugs.
Method:
The preparation method of tert-butyl is as follows:
1. Reaction of tert-butyl 3-amino-1-carboxylate with hydrogen fluoride under appropriate reaction conditions to give tert-butyl 3-fluoro-1-carboxylate.
2. Reaction of tert-butyl 3-fluoro-1-carboxylate with 4-chloropiperidine under basic conditions gives tert-butyl 3-fluoro-4-chloropiperidine-1-carboxylate.
3. Finally, 3-fluoro-4-chloropiperidine-1-carboxylic acid tert-butyl ester is oxidized to obtain the final product tert-butyl.
Safety Information:
- tert-butyl is an organic compound with certain toxicity and should comply with laboratory safety procedures.
-Avoid contact with skin and eyes, pay attention to protective measures.
-During storage and handling, attention should be paid to prevent ignition and electrostatic sparks.
-If taken by mistake or inhaled, seek medical attention immediately and provide the appropriate safety data sheet.
Last Update：2024-04-09 21:00:56
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Product Name: tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Request for quotationCAS: 211108-50-8
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Product Name: tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Request for quotation
CAS: 211108-50-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 211108-50-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
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